Publications

Harnessing lentiviral vectors for in vivo gene therapy of liver metastases.

Giacca G, Naldini L, Squadrito ML.

Clin Transl Med. 2024 Jan;14(1):e1542. doi: 10.1002/ctm2.1542.

PDF

VEGF-C-expressing TAMs rewire the metastatic fate of breast cancer cells.

Banerjee K, Kerzel T, Bekkhus T, de Souza Ferreira S, Wallmann T, Wallerius M, Landwehr LS, Agardy DA, Schauer N, Malmerfeldt A, Bergh J, Bartish M, Hartman J, Östman A, Squadrito ML, Rolny C.

Cell Rep. 2023 Dec 26;42(12):113507. doi: 10.1016/j.celrep.2023.113507. Epub 2023 Dec 1.

PDF

In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases

PDF

HTATIP2 regulates arteriogenic activity in monocytes from patients with limb ischemia

Patel AS, Ludwinski FE, Mondragon A, Nuthall K, Saha P, Lyons O, Squadrito ML, Siow RC, De Palma M, Smith A, Modarai B.

TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells

Delfanti G, Cortesi F, Perini A, Antonini G, Azzimonti L, de Lalla C, Garavaglia C, Squadrito ML, Fedeli M, Consonni M, Sesana S, Re F, Shen H, Dellabona P, Casorati G. 

Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth

Bernier-Latmani J, Cisarovsky C, Mahfoud S, Ragusa S, Dupanloup I, Barras D, Renevey F, Nassiri S, Anderle P, Squadrito ML, Siegert S, Davanture S, González-Loyola A, Fournier N, Luther SA, Benedito R, Valet P, Zhou B, De Palma M, Delorenzi M, Sempoux C, Petrova TV. 

MNK2 governs the macrophage antiinflammatory phenotype.

Bartish M, Tong D, Pan Y, Wallerius M, Liu H, Ristau J, de Souza Ferreira S, Wallmann T, van Hoef V, Masvidal L, Kerzel T, Joly AL, Goncalves C, Preston SEJ, Ebrahimian T, Seitz C, Bergh J, Pietras K, Lehoux S, Naldini L, Andersson J, Squadrito ML, Del Rincón SV, Larsson O, Rolny C.
Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27556-27565. 

Laboratory-Scale Lentiviral Vector Production and Purification for Enhanced Ex Vivo and In Vivo Genetic Engineering.

Soldi M, Sergi Sergi L, Unali G, Kerzel T, Cuccovillo I, Capasso P, Annoni A, Biffi M, Rancoita PMV, Cantore A, Lombardo A, Naldini L, Squadrito ML*, Kajaste-Rudnitski A*.
Mol Ther Methods Clin Dev. 2020 Oct 20;19:411-425. 
PDF

Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice.

Ragusa S, Prat-Luri B, González-Loyola A, Nassiri S, Squadrito ML, Guichard A, Cavin S, Gjorevski N, Barras D, Marra G, Lutolf MP, Perentes J, Corse E, Bianchi R, Wetterwald L, Kim J, Oliver G, Delorenzi M, De Palma M, Petrova TV.
J Clin Invest. 2020 Mar 2;130(3):1199-1216.

Antiangiogenic immunotherapy s Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer.

Evans R, Flores-Borja F, Nassiri S, Miranda E, Lawler K, Grigoriadis A, Monypenny J, Gillet C, Owen J, Gordon P, Male V, Cheung A, Noor F, Barber P, Marlow R, Francesch-Domenech E, Fruhwirth G, Squadrito M, Vojnovic B, Tutt A, Festy F, De Palma M, Ng T.
Cell Rep. 2019 May 14;27(7):1967-1978.e4. 

Sequential Bone-Marrow Cell Delivery of VEGFA/S1P Improves Vascularization and Limits Adverse Cardiac Remodeling After Myocardial Infarction in Mice.

Żak MM, Gkontra P, Clemente C, Squadrito ML, Ferrarini A, Mota RA, Oliver E, Rocha S, Agüero J, Vázquez J, De Palma M, Ibáñez B, Arroyo AG.
Hum Gene Ther. 2019 Jul;30(7):893-905.

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models.

Keklikoglou I, Cianciaruso C, Güç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C, Cassará A, Guichard A, Iruela-Arispe ML, Lewis CE, Coussens LM, Bardia A, Jain RK, Pollard JW, De Palma M.
Nat Cell Biol. 2019 Feb;21(2):190-202. 

EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens.

Squadrito ML, Cianciaruso C, Hansen SK, De Palma M.
Nat Methods. 2018 Mar;15(3):183-186. 
PDF

Precision Targeting of Tumor Macrophages with a CD206 Binding Peptide.

Scodeller P, Simón-Gracia L, Kopanchuk S, Tobi A, Kilk K, Säälik P, Kurm K, Squadrito ML, Kotamraju VR, Rinken A, De Palma M, Ruoslahti E, Teesalu T.
Sci Rep. 2017 Nov 7;7(1):14655. 

Perivascular Macrophages Limit Permeability.

He H, Mack JJ, Güç E, Warren CM, Squadrito ML, Kilarski WW, Baer C, Freshman RD, McDonald AI, Ziyad S, Swartz MA, De Palma M, Iruela-Arispe ML.
Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2203-2212. 

Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p.

Zhou Y, Do DC, Ishmael FT, Squadrito ML, Tang HM, Tang HL, Hsu MH, Qiu L, Li C, Zhang Y, Becker KG, Wan M, Huang SK, Gao P.J Allergy Clin Immunol. 2018 Jan;141(1):350-364.e8.

DICERing macrophages for reprogramming TAMs.

Squadrito ML, De Palma M.
Cell Cycle. 2016 Dec;15(23):3149-3150. 

Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumour immunity.

Baer C, Squadrito ML, Laoui D, Thompson D, Hansen SK, Kiialainen A, Hoves S, Ries CH, Ooi CH, De Palma M.
Nat Cell Biol. 2016 Jul;18(7):790-802.
PDF

TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation.

Ferri F, Parcelier A, Petit V, Gallouet AS, Lewandowski D, Dalloz M, van den Heuvel A, Kolovos P, Soler E, Squadrito ML, De Palma M, Davidson I, Rousselet G, Romeo PH.
Nat Commun. 2015 Nov 23;6:8900.

Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages.

Wallerius M, Wallmann T, Bartish M, Östling J, Mezheyeuski A, Tobin NP, Nygren E, Pangigadde P, Pellegrini P, Squadrito ML, Pontén F, Hartman J, Bergh J, De Milito A, De Palma M, Östman A, Andersson J, Rolny C.Cancer Res. 2016 Jun 1;76(11):3166-78.

miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation.

Heinsbroek SE, Squadrito ML, Schilderink R, Hilbers FW, Verseijden C, Hofmann M, Helmke A, Boon L, Wildenberg ME, Roelofs JJ, Ponsioen CY, Peters CP, Te Velde AA, Gordon S, De Palma M, de Jonge WJ.
Mucosal Immunol. 2016 Jul;9(4):960-73.

miR-135a Inhibits Cancer Stem Cell-Driven Medulloblastoma Development by Directly Repressing Arhgef6 Expression.

Hemmesi K, Squadrito ML, Mestdagh P, Conti V, Cominelli M, Piras IS, Sergi LS, Piccinin S, Maestro R, Poliani PL, Speleman F, De Palma M, Galli R.
Stem Cells. 2015 May;33(5):1377-89.

A niche role for periostin and macrophages in glioblastoma.

Squadrito ML, De Palma M.
Nat Cell Biol. 2015 Feb;17(2):107-9. 

A niche role for periostin and macrophages in glioblastoma.

Squadrito ML, De Palma M.
Nat Cell Biol. 2015 Feb;17(2):107-9. 

Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells.

Squadrito ML, Baer C, Burdet F, Maderna C, Gilfillan GD, Lyle R, Ibberson M, De Palma M.
Cell Rep. 2014 Sep 11;8(5):1432-46. 
PDF

Micromanaging restenosis by therapeutic inhibition of miR-92a.

Squadrito ML, De Palma M.
Cardiovasc Res. 2014 Sep 1;103(4):432-4.

Cellular magnetic resonance with iron oxide nanoparticles: long-term persistence of SPIO signal in the CNS after transplanted cell death.

Cianciaruso C, Pagani A, Martelli C, Bacigaluppi M, Squadrito ML, Lo Dico A, De Palma M, Furlan R, Lucignani G, Falini A, Biffi A, Ottobrini L, Politi LS.
Nanomedicine (Lond). 2014 Jul;9(10):1457-74. 

Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression.

Escobar G, Moi D, Ranghetti A, Ozkal-Baydin P, Squadrito ML, Kajaste-Rudnitski A, Bondanza A, Gentner B, De Palma M, Mazzieri R, Naldini L.
Sci Transl Med. 2014 Jan 1;6(217):217ra3. 

Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression.

Escobar G, Moi D, Ranghetti A, Ozkal-Baydin P, Squadrito ML, Kajaste-Rudnitski A, Bondanza A, Gentner B, De Palma M, Mazzieri R, Naldini L.
Sci Transl Med. 2014 Jan 1;6(217):217ra3. 

PHD2 regulates arteriogenic macrophages through TIE2 signalling.

Hamm A, Veschini L, Takeda Y, Costa S, Delamarre E, Squadrito ML, Henze AT, Wenes M, Serneels J, Pucci F, Roncal C, Anisimov A, Alitalo K, De Palma M, Mazzone M.
EMBO Mol Med. 2013 Jun;5(6):843-57.

Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches.

Baer C, Squadrito ML, Iruela-Arispe ML, De Palma M.
Exp Cell Res. 2013 Jul 1;319(11):1626-34. 

MicroRNA-mediated control of macrophages and its implications for cancer.

Squadrito ML, Etzrodt M, De Palma M, Pittet MJ.
Trends Immunol. 2013 Jul;34(7):350-9.

miR-511-3p modulates genetic programs of tumor-associated macrophages.

Squadrito ML, Pucci F, Magri L, Moi D, Gilfillan GD, Ranghetti A, Casazza A, Mazzone M, Lyle R, Naldini L, De Palma M.
Cell Rep. 2012 Feb 23;1(2):141-54.
PDF

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis.

Takeda Y, Costa S, Delamarre E, Roncal C, Leite de Oliveira R, Squadrito ML, Finisguerra V, Deschoemaeker S, Bruyère F, Wenes M, Hamm A, Serneels J, Magat J, Bhattacharyya T, Anisimov A, Jordan BF, Alitalo K, Maxwell P, Gallez B, Zhuang ZW, Saito Y, Simons M, De Palma M, Mazzone M.
Nature. 2011 Oct 9;479(7371):122-6. 

Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase.

Sharda DR, Yu S, Ray M, Squadrito ML, De Palma M, Wynn TA, Morris SM Jr, Hankey PA.
J Immunol. 2011 Sep 1;187(5):2181-92.

Macrophage regulation of tumor angiogenesis: implications for cancer therapy.

Squadrito ML, De Palma M.
Mol Aspects Med. 2011 Apr;32(2):123-45.

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.

Rolny C, Mazzone M, Tugues S, Laoui D, Johansson I, Coulon C, Squadrito ML, Segura I, Li X, Knevels E, Costa S, Vinckier S, Dresselaer T, Åkerud P, De Mol M, Salomäki H, Phillipson M, Wyns S, Larsson E, Buysschaert I, Botling J, Himmelreich U, Van Ginderachter JA, De Palma M, Dewerchin M, Claesson-Welsh L, Carmeliet P.
Cancer Cell. 2011 Jan 18;19(1):31-44.

Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models.

Casazza A, Fu X, Johansson I, Capparuccia L, Andersson F, Giustacchini A, Squadrito ML, Venneri MA, Mazzone M, Larsson E, Carmeliet P, De Palma M, Naldini L, Tamagnone L, Rolny C.
Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):741-9.

www.cancerbiotechnology.com – Thanks for visiting our website!