Publications
Selected publications (2016 - 2024)
In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases
Kerzel T, Giacca G, Beretta S, Bresesti C, Notaro M, Scotti GM, Balestrieri C, Canu T, Redegalli M, Pedica F, Genua M, Ostuni R, Kajaste-Rudnitski A, Oshima M, Tonon G, Merelli I, Aldrighetti L, Dellabona P, Coltella N, Doglioni C, Rancoita PMV, Sanvito F, Naldini L, Squadrito ML.
Cancer Cell 2023
Genotoxic effects of base and prime editing in human hematopoietic stem cells
Fiumara M*, Ferrari S*, Omer-Javed A, Beretta S, Albano L, Canarutto D, Varesi A, Gaddoni C, Brombin C, Cugnata F, Zonari E, Naldini MM, Barcella M, Gentner B, Merelli I, Naldini L.
Nature Biotechnology 2023
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells
Vavassori V, Ferrari S, Beretta S, Asperti C, Albano L, Annoni A, Gaddoni C, Varesi A, Soldi M, Cuomo A, Bonaldi T, Radrizzani M, Merelli I, Naldini L.
Blood 2023
Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells
Attya Omer-Javed, Gabriele Pedrazzani, Luisa Albano, Sherash Ghaus, Claire Latroche, Maura Manzi, Samuele Ferrari, Martina Fiumara, Aurelien Jacob, Valentina Vavassori, Alessandro Nonis, Daniele Canarutto, Luigi Naldini
Cell 2022
Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models
Filippo Birocchi, Melania Cusimano,, Federico Rossari, Stefano Beretta, Paola M V Rancoita, Anna Ranghetti, Stefano Colombo, Barbara Costa, Peter Angel, Francesca Sanvito, Marcella Callea, Rossana Norata, Linda Chaabane, Tamara Canu, Antonello Spinelli, Marco Genua, Renato Ostuni, Ivan Merelli, Nadia Coltella*, Luigi Naldini*
Science Translational Medicine 2022
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells
Samuele Ferrari, Aurelien Jacob, Daniela Cesana, Marianne Laugel, Stefano Beretta, Angelica Varesi, Giulia Unali, Anastasia Conti, Daniele Canarutto, Luisa Albano, Andrea Calabria, Valentina Vavassori, Carlo Cipriani, Maria Carmina Castiello, Simona Esposito, Chiara Brombin, Federica Cugnata, Oumeya Adjali, Eduard Ayuso, Ivan Merelli, Anna Villa, Raffaella Di Micco, Anna Kajaste-Rudnitski, Eugenio Montini, Magalie Penaud-Budloo, Luigi Naldini
Cell Stem Cell 2022
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome
Valentina Vavassori, Elisabetta Mercuri, Genni E Marcovecchio, Maria C Castiello, Giulia Schiroli, Luisa Albano, Carrie Margulies, Frank Buquicchio, Elena Fontana, Stefano Beretta , Ivan Merelli, Andrea Cappelleri, Paola Rancoita, Vassilios Lougaris, Alessandro Plebani, Maria Kanariou, Arjan Lankester, Francesca Ferrua, Eugenio Scanziani, Cecilia Cotta-Ramusino, Anna Villa, Luigi Naldini*, Pietro Genovese*
EMBO Molecular Medicine 2021
Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking
Samuele Ferrari*, Aurelien Jacob*, Stefano Beretta, Giulia Unali, Luisa Albano, Valentina Vavassori, Davide Cittaro, Dejan Lazarevic, Chiara Brombin, Federica Cugnata, Anna Kajaste-Rudnitski, Ivan Merelli, Pietro Genovese* & Luigi Naldini*
Nature Biotechnology 2020
Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response
Giulia Schiroli*, Anastasia Conti*, Samuele Ferrari, Lucrezia Della Volpe, Aurelien Jacob, Luisa Albano, Stefano Beretta, Andrea Calabria, Valentina Vavassori, Patrizia Gasparini, Eralda Salataj, Delphine Ndiaye-Lobry, Chiara Brombin, Julie Chaumeil, Eugenio Montini, Ivan Merelli, Pietro Genovese*, Luigi Naldini*, Raffaella Di Micco*
Cell Stem Cell 2019
Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates
Michela Milani, Andrea Annoni, Federica Moalli, Tongyao Liu, Daniela Cesana, Andrea Calabria, Sara Bartolaccini, Mauro Biffi, Fabio Russo, Ilaria Visigalli, Andrea Raimondi, Susannah Patarroyo-White, Douglas Drager, Patrizia Cristofori, Eduard Ayuso 6, Eugenio Montini, Robert Peters, Matteo Iannacone, Alessio Cantore*, Luigi Naldini*
Science Translational Medicine 2019
EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens
Mario Leonardo Squadrito, Chiara Cianciaruso, Sarah K Hansen, Michele De Palma
Nature Methods 2018
Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
Giulia Escobar, Luigi Barbarossa, Giulia Barbiera, Margherita Norelli, Marco Genua, Anna Ranghetti, Tiziana Plati, Barbara Camisa, Chiara Brombin, Davide Cittaro, Andrea Annoni, Attilio Bondanza, Renato Ostuni, Bernhard Gentner*, Luigi Naldini*
Nature Communications 2018
Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumour immunity
Caroline Baer*, Mario Leonardo Squadrito*, Damya Laoui, Danielle Thompson, Sarah K Hansen, Anna Kiialainen, Sabine Hoves, Carola H Ries, Chia-Huey Ooi, Michele De Palma
Nature Cell Biology 2016
miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia
Silvia Nucera, Alice Giustacchini, Francesco Boccalatte, Andrea Calabria, Cristiana Fanciullo, Tiziana Plati, Anna Ranghetti, Jose Garcia-Manteiga, Davide Cittaro, Fabrizio Benedicenti, Eric R Lechman, John E Dick, Maurilio Ponzoni, Fabio Ciceri, Eugenio Montini, Bernhard Gentner*, Luigi Naldini*
Cancer Cell 2016
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing
Angelo Amabile*, Alessandro Migliara*, Paola Capasso, Mauro Biffi, Davide Cittaro, Luigi Naldini*, Angelo Lombardo*
Cell 2016
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